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280 In a rat model of LPS-induced inflammation, systemic Trx significantly reduced neutrophil infiltration in the bronchus and lung tissues, but did not directly reduce the increased LPS-induced ICAM-1 present on the endothelial cells

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In AD, oxidative stress also plays a central role promoting A accumulation and tau phosphorylation [191] and impairing proteostasis (the homeostasis of protein folding, stability, and degradation), synaptic plasticity and other processes critical for learning and memory [188, 192]